New research reveals that people who stop using blockbuster GLP-1 drugs like Wegovy and Mounjaro may regain lost weight far faster than those who end conventional diet and exercise programs.
Findings released in a major medical journal points out that while overweight individuals can lose substantial amounts of their total mass while undergoing treatment, the weight returns at an estimated rate of nearly a kilo each month upon discontinuation.
"Users buying these treatments must be aware of the potential of fast weight regain when the treatment ends," cautioned expert Dr. Susan Jebb.
This pace of regain suggests a reversion to original weight within about 18 months.
Comparing Treatments
The study, which examined dozens of studies involving over 9,000 of participants, contrasted the results of the injectable medications with older methods.
Scientists note that individuals who lose weight through diet and exercise usually see a more gradual weight regain—perhaps 0.1 kg a month—once they finish.
Explaining the Rapid Regain
Doctors suggest the way of the injections is key to understanding the heightened rebound.
GLP-1 drugs copy a body's own chemical called glucagon-like peptide-1, which moderates appetite.
"Artificially providing GLP-1 levels several times higher than the body's typical production may cause the body to generate a reduced amount of its own natural hormone, and could reduce responsiveness to its effects," noted Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this medication leads to hunger is uncontrolled, making overeating much more probable."
A Lifelong Issue?
Medical guidelines recommend the jabs for people with weight-linked medical conditions, alongside prescribed diet and exercise modifications.
Many experts argue that, considering the significant potential of weight regain, the therapy should be considered ongoing.
This opinion is echoed by drug manufacturers, who say that the results "underscore the long-term character of obesity," akin to managing conditions like diabetes.
Patient Accounts
Individuals who have stopped the medication describe a powerful resurgence of cravings.
"It felt as if a switch flipping and you become starving," recalled one woman.
This difficulty is exacerbated if individuals have not developed lasting dietary or behavioural modifications during treatment.
Significant Use
Recent estimates indicate that a significant number of adults in the UK have used these injections in the past year, with desire being substantial.
- Adoption is higher among women than men.
- The middle-aged age group shows the highest level of interest.
- A large proportion access the drugs through private healthcare rather than the NHS.
In conclusion, clinicians stress that while the jabs are powerful agents for weight loss, they are not a permanent solution and maintained weight loss likely depends on ongoing behavioural changes.
